16 Top Methylation Gene Tests for Optimal Health

Discover the best methylation gene test to unlock your health secrets quickly and confidently with our expert tips and top picks.
BrandMy RatingPrice
Empowerdx
Best Price-to-Performance
7.8/10
Mthfr
Best for Mental Health Support
9.4/10
Tellmegen
Best for In-Depth Genetic Insights
8.4/10
Plexusdx
Best for Holistic Wellness
9.6/10
Lifedna
8.4/10

Best Methylation Gene Test

Unlock the secrets hidden within your DNA with the best methylation gene test, a powerful tool to decode your body's intricate biochemical symphony. As you embark on a journey to optimize your health, discover how pinpointing methylation pathways can illuminate the path to personalized wellness. Dive in to reveal the hidden layers of your genetic blueprint and empower your health story.

Best Price-to-Performance: EmpowerDX MTHFR Test

MTHFR Gene Test Kit, Methylation Test, Easy at-Home Test Detects Presence of 677 and 1298 MTHFR Gene Variants, Ages 2+, Fast Results Within 6 Days
Highlights
Easy at-home sample collection
Secure online results
Certified laboratory testing

This budget-friendly test zeroes in on the key MTHFR variants (677 and 1298), giving you clear insights into your methylation health without breaking the bank.

The easy-to-use mouth swab makes sample collection a breeze — perfect for at-home testing.

Plus, with testing done at a certified lab, you can trust the accuracy of your results.

The results are delivered securely online with helpful guidance on interpretation.

While the test limits its scope to specific variants and requires prompt activation, it’s a cost-effective choice for anyone wanting quick, essential info on their genetic health.

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Price history for EmpowerDX MTHFR Test on Amazon

Best for Mental Health Support: MTHFR Gene Test Kit

COMT Gene Test Collection Kit Comes with Results Interpretation and Live Support 7 Days a Week - Cheek Swab -
Highlights
Live support available
Easy at-home collection
Fast and accurate results

As "Best for Mental Health Support," it truly delivers personalized insights by analyzing your MTHFR and COMT genes, which are crucial for cognitive function and emotional well-being.

The live phone support is a game-changer, offering real-time guidance to help interpret your results and understand their implications.

Plus, the simple cheek swab makes sample collection hassle-free—even for little ones!

With fast turnaround times and trusted accuracy, this kit empowers you to make informed lifestyle choices with confidence.

Overall, a solid, user-friendly option for those prioritizing mental health clarity.

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Price history for MTHFR Gene Test Kit on Amazon

Best for In-Depth Genetic Insights: tellmeGen

tellmeGen Advanced DNA Test Kit with 400+ Health, Ancestry, Traits & Fitness Reports, Personalized Genetic Reports and DNA Relative Connect with Lifetime Updates Included
Highlights
Comprehensive genetic analysis
Easy saliva collection
Expert support available

Delivers a massive amount of data with over 400 personalized reports covering health risks, ancestry, and personal traits.

Plus, the option for pharmacogenetic and nutrigenetic insights through expert consultation really sets it apart.

It’s perfect for those who crave in-depth genetic understanding.

The process is straightforward—just saliva, activation online, and results in 4-6 weeks.

We appreciate the lifetime updates that keep your insights current, and the strong privacy measures give peace of mind.

While some details can be complex to interpret, the dedicated support team is always ready to help make sense of the data.

A solid choice for serious genetic explorers!

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Price history for tellmeGen on Amazon

Best for Holistic Wellness: PlexusDX MTHFR & Methylation Test

MTHFR + Methylation Comprehensive Genetic Test Kit | 95+ DNA Reports Including MTHFR, COMT, BHMT, and Folate | Custom Supplement & Meal Plan Recommendations with 10,000+ Recipes
Highlights
Easy, straightforward process
Detailed, actionable reports
Affordable compared to others

It offers a comprehensive methylation gene analysis, covering key genes like AHCY, BHMT, CBS, and more, giving you a detailed look at your body's methylation pathways.

The reports are practical and easy to understand, with actionable insights for diet, supplements, and lifestyle tweaks.

Plus, it provides personalized meal plans with thousands of recipes tailored to your genetic makeup—perfect for those want to optimize their health holistically.

While it does require mailing a sample and results take a few weeks, the affordability and depth of information make this a top choice for anyone serious about customizing their wellness journey.

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Price history for PlexusDX MTHFR & Methylation Test on Amazon

LIFEDNA Methylation Genes Test

Methylation Genes Test Kit Includes MTHFR Analysis | Analyzes 12 Methylation Gene Variants (MTHFR, COMT, and VDR) | Easy at-Home Testing | Fast Results
Highlights
Easy to use
Clear, actionable insights
Expert consultation included

The kit is straightforward and user-friendly, making at-home testing a breeze.

It covers 12 critical methylation gene variants, giving you a comprehensive view of your genetic makeup related to energy, mood, and metabolism.

Plus, the expert consultation helps translate your results into personalized action steps, which is a real bonus.

While the wait time of 3-5 weeks is a bit lengthy, the clear, actionable insights and the fact that your data is secure and entirely yours make this a top choice.

Overall, a reliable, informative option for anyone serious about optimizing their health.

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Price history for LIFEDNA Methylation Genes Test on Amazon

LIFEDNA Methylation Genes Test

12 Methylation Genes Test with Complete Wellness Analysis | at-Home DNA Testing Kit | Over 120 Traits Into Your Nutrition, Fitness, Vitamins, Wellness, Sleep, Skincare
Highlights
Comprehensive gene analysis
Detailed wellness reports
Expert consultation available

The test covers 12 key gene variants, including MTHFR, COMT, and CBS, giving you a comprehensive look at your methylation cycle.

It not only pinpoints potential factors influencing your energy and mood but also offers 7 extra wellness reports—think sleep, nutrition, and personality insights—making it a true all-in-one package.

With labs in the USA and strict data security, you can trust your results are both accurate and protected.

Plus, the option to consult with an expert ensures you won't be left guessing—making this a top-tier choice for personalized health exploration.

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Price history for LIFEDNA Methylation Genes Test on Amazon

MTHFR.com Methylation Gene Test

MTHFR Methylation Gene Test Kit. 1-on-1 Live Expert Support by Phone 7 Days A Week, C677T and A1298C Gene Variants for Methylation Analysis. Results Within a Week. Ages 0+
Highlights
Easy cheek swab collection
Expert guidance available
Detailed, thorough results

The comprehensive mutation analysis ensures you get a clear picture of all MTHFR gene mutations, giving you confidence in your results.

Plus, the easy cheek swab makes sample collection stress-free and painless—perfect for all ages, even little ones.

The personalized supplement recommendations based on Ricardo Miranda’s proven protocol add a tailored touch that truly sets this test apart.

Their expert support team is available seven days a week, ready to answer questions or connect you directly with Miranda himself if needed.

While results take a few weeks, the accuracy and detailed insights make it well worth the wait.

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Price history for MTHFR.com on Amazon

MTHFR.com

MTHFR + COMT Methylation Genes Test Kit. 1-on-1 Live Expert Support by Phone 7 Days A Week. C677T, A1298C and V158M Gene Variants for Methylation Analysis +. Results Within 1 Week. Ages 0+
Highlights
Easy home collection
Expert guidance available
Accurate genetic insights

The MTHFR Doctors kit offers easy at-home collection with straightforward instructions, even for little ones—just a quick cheek swab, no fuss.

The expert guidance available by phone ensures you’re never in the dark about your results, which are highly accurate and focused on the critical MTHFR and COMT genes.

Although results can sometimes take a bit longer, the privacy and security standards are top-notch, giving us peace of mind.

Overall, it's a reliable, science-backed choice for anyone serious about understanding their methylation profile and making informed health decisions.

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Price history for MTHFR.com on Amazon

23andMe

23andMe Health + Ancestry Service: Personal Genetic DNA Test Including Health Predispositions, Carrier Status, Wellness, and Trait Reports (Before You Buy See Important Test Info Below)
Highlights
Easy at-home testing
Science-backed health insights
Data privacy ensured

23andMe’s at-home DNA test offers a comprehensive look at your genetic makeup, including methylation gene insights that can reveal your body's unique processes.

The test is super simple—just spit into the tube and send it back—no needles needed.

You’ll get science-backed reports that help decode your health risks and lifestyle factors, empowering you to take informed actions.

Plus, your data privacy is a top priority, giving you peace of mind.

While results take about 4-5 weeks, the quality and depth of insights make it well worth the wait.

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Price history for 23andMe on Amazon

5Strands Nutrition Imbalance Test Methylation Gene Test

5Strands Nutrition Imbalance Test, 83 Vitamins, Minerals, Amino Acid Imbalances Tested, Supplement Absorption, at Home Nutrition Test for Adults & Kids, Hair Analysis, Results in 4 Days
Highlights
Easy at-home testing
Identifies nutrient imbalances
Backed by experts

The at-home hair analysis makes it super easy to uncover nutrient absorption issues without the hassle of clinic visits.

Their comprehensive testing covers over 80 vitamins and minerals, giving you a clear picture of where your body might be lagging—whether it's mild or severe.

Backed by functional medicine experts, it's a trustworthy tool to help tailor your diet and supplements.

While it’s not perfect—some vitamin results can seem inconsistent and it’s limited to hair analysis—the ease and professional backing make this a solid choice for those looking to optimize health through personalized insights.

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Price history for 5Strands Nutrition Imbalance Test on Amazon

23andMe

23andMe+ Premium Membership Bundle - DNA Kit with Personal Genetic Insights Including Health + Ancestry Service Plus 1-Year Access to Exclusive Reports (Before You Buy See Important Test Info Below)
Highlights
Detailed health insights
Easy and quick process
Comprehensive ancestry info

The comprehensive health insights provide a clear look into your methylation gene profile, helping you understand your body’s processes more deeply.

The easy and quick process makes genetic testing hassle-free—no longer than a coffee break!

Plus, the extensive ancestry information adds a fun, educational layer, connecting you with your roots.

While privacy concerns are worth noting and some features come with extra costs, the detailed reports and ongoing value make it a standout choice for those serious about their health and heritage.

Overall, it’s a reliable, well-rounded option worth considering.

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Price history for 23andMe on Amazon

23andMe

23andMe Ancestry Service - DNA Test Kit with Personalized Genetic Reports Including Ancestry Composition with 4000+ Geographic Regions, Family Tree, DNA Relative Finder and Trait Reports
Highlights
Easy at-home collection
Detailed ancestry reports
Connects DNA relatives

The at-home saliva kit makes the process super simple—spit, register, and send.

The 80+ personalized reports deliver a deep dive into your ancestry, from geographic origins to family timelines, providing a rich context about your roots.

Plus, the DNA Relative Finder is a fun way to connect with potential relatives.

While the processing time can be a bit sluggish and occasional kits may fail, the detailed ancestry insights and privacy controls outweigh these minor drawbacks.

Overall, it’s a solid choice for anyone curious about their genetic background.

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Price history for 23andMe on Amazon

Advanced Food Intolerance Labs Methylation Gene Test

AFIL | Food, Drinks & Vitamin Sensitivity Testing Kit for Adults & Kids | 750+ Items, Gluten, Dairy, Vitamin D | Fast Results
Highlights
Quick results in 3 days
At-home hair sample
Trusted ISO certified lab

The at-home hair kit makes it incredibly easy—just a few strands of hair, no blood or needles needed.

Results come back within 3 days, so you won’t be left waiting forever to understand your sensitivities.

Plus, the trusted ISO-certified lab ensures reliable science behind your results.

The exclusive member portal adds value with personalized diet plans, recipes, and supplement suggestions tailored specifically for you.

However, keep in mind that the results lack detailed numerical data and are limited to U.

S. residents.

Overall, it’s a quick, convenient, and science-backed option for uncovering food sensitivities effectively.

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Price history for Advanced Food Intolerance Labs on Amazon

5Strands Food Intolerance Test

5Strands Food Intolerance Test, 640 plus Items Tested, Food Sensitivity at Home Test Kit for Adults & Kids, Accurate Hair Analysis, Results in 5 Days
Highlights
Easy to use at home
Comprehensive food coverage
Clinically endorsed

The 5Strands food sensitivity test offers a comprehensive look at potential food intolerances, covering 640 items across 14 categories—from dairy to spices.

It’s super easy to do at home, just register online, collect your hair sample, and ship it back with prepaid packaging.

The results arrive in about five days, giving you quick insights to tailor your diet.

Clinically endorsed and trusted by functional medicine professionals, it’s a powerful tool to identify triggers and start your healing journey.

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Price history for 5Strands Food Intolerance Test on Amazon

5Strands

5Strands Intolerances & Nutritional Imbalance Test, 442 Items Tested, Food Intolerance, Environment Sensitivity, Nutrition Absorption for Adults & Kids, Results in 4 Days
Highlights
Comprehensive food & nutrient insights
Approved by functional doctors
Easy, pain-free at-home test

The 5Strands Sensitivity & Imbalances test offers an extensive look into over 440 food, environmental, and nutritional items, helping you pinpoint intolerances and deficiencies with ease.

It’s approved by functional medicine doctors, so you know it’s credible.

The process is completely pain-free and can be done at home, which makes it convenient for busy schedules.

Once you get your results, you can take clear, targeted steps to improve your health.

Keep in mind, patience is key, as noticeable changes take time.

Overall, it’s a smart, simple choice for proactive wellness.

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Price history for 5Strands on Amazon

Neurobiologix Methylation Complete Methylation Gene Test

Methylation Complete in Fast-Dissolving Tablets - Methylated B Complex Vitamins to Aid Over 200 Body Processes - Supports Energy, Cell Function & Immunity - Enhanced Absorption with B12, B6 & Folate
Highlights
Supports 200+ functions
Rapid absorption technology
Suitable for sensitive diets

Neuro Biologix methylated vitamins support over 200 vital functions, boosting energy, immune health, and cellular activities.

The rapid absorption technology ensures you feel the benefits fast, making it a convenient choice for busy lifestyles.

Its formulation, rich in B6, B12, and Folate, is optimized for brain function and overall vitality.

Plus, it’s ideal for vegetarians and those with sensitive digestion, thanks to its unique delivery method.

While the taste can vary and it requires sublingual dissolving, the holistic boost to mood, nerve health, and immune response makes it a top contender in methylation support.

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Price history for Neurobiologix Methylation Complete on Amazon

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