12 Probiotic for Colic Options for Calm and Happy Babies

Discover the best probiotic for colic with our quick, colorful guide to soothe your baby’s tummy and bring comfort with ease
BrandMy RatingPrice
Biogaia
Top Low-Cost Selection
9.0/10
Biogaia
Top Low-Cost Selection
9.0/10
Mommy's Bliss
Best for Colic Relief
9.0/10
Lovebug Probiotics
Best for Digestive Support
8.6/10
Culturelle
9.0/10

Best Probiotic for Colic

Discover the soothing power of probiotics and unlock gentle relief for your little one’s colic discomfort. In our quest for the best probiotic for colic, we’ve sifted through the most effective, safe, and gentle options that bring comfort with every dose. Get ready to navigate the world of probiotics and find the perfect match to help your baby settle into peaceful, happy moments.

Top Low-Cost Selection: BioGaia

BioGaia Protectis Baby Probiotic Drops | Baby Essentials for Colic & Gas Relief | Safe for Newborns | Ease Crying, Fussing, Colic, Gas, Spit-ups & Constipation | No Dairy, Soy & Gluten | 5mL
Highlights
Relieves colic and gas
Safe for newborns
Natural breast milk ingredients

BioGaia Baby is the top low-cost selection for colic relief, offering a highly researched probiotic backed by extensive studies.

It naturally works within the digestive system to soothe fussiness, gas, spit-ups, and even occasional discomfort.

Plus, it’s safe for newborns from day one—free from allergens, dairy, soy, gluten, and artificial ingredients.

While it may take a few days to see results and some bottles might be underfilled, the scientifically validated ingredients and trusted safety profile make it a smart, affordable choice for parents seeking gentle, effective relief.

Be sure to also check out the best probiotic for lactose intolerance for more options! Also, here is the price history so you know exactly when to buy!

Price history for BioGaia on Amazon

Best for Colic Relief: Mommy's Bliss

Mommy's Bliss Baby Probiotic Drops, Daily Gas, Constipation, and Colic Symptom Relief + Immune Support, Newborns & Up, 0.34 Fl Oz (30 Servings)
Highlights
Supports digestive health
pediatrician recommended
Easy squeeze bottle

Mommy's Bliss Baby Probiotic Drops Everyday are clinically shown to reduce crying and fussiness, making them our top pick for best probiotic for colic.

Backed by trusted pediatricians and crafted with the most researched probiotic strains, these drops support a healthy gut and soothe stomach discomfort.

The easy-squeeze bottle makes administration simple for busy parents, though you'll want to be mindful of the small size and heat sensitivity.

Overall, this probiotic offers gentle, effective relief without fuss, helping little ones feel happier and more comfortable.

Be sure to also check out the best probiotics for liver for more options! Also, here is the price history so you know exactly when to buy!

Price history for Mommy's Bliss on Amazon

Best for Digestive Support: Lovebug Probiotics

Lovebug Award Winning USDA Organic Probiotic for Infants & Babies | Helps with Colic, Reflux, Diarrhea, Constipation & Gas | Multi-Strain 5 Billion CFU | Liquid Drops | Ages 0-24 Months
Highlights
Includes Vitamin D
Effective digestion support
Organic and allergen-free

Lovebug Probiotics stands out as the best for digestive support for little ones aged 0-12 months.

Crafted with multi-strain organic probiotics, it offers comprehensive immune and digestive benefits.

The added Vitamin D helps build strong bones, while its allergen-free, USDA Organic certification ensures safety and purity—perfect for sensitive baby tummies.

Although the dropper can be a bit tricky to measure accurately, the effectiveness and quality assurance more than make up for it.

Overall, it's a trusted choice for parents seeking a gentle, natural way to ease colic and promote healthy digestion in their infants.

Be sure to also check out the best probiotics for alcohol drinkers for more options! Also, here is the price history so you know exactly when to buy!

Price history for Lovebug Probiotics on Amazon

Culturelle Baby

Culturelle Baby Digestive Calm & Comfort Probiotic (Age 0-12 Mos) 8.5Ml, Helps Periodic Colic, Gas, Fussiness, Crying & Digestive Upset In Infants & Newborns, Vegan Non-Gmo Gluten-Free, 1 Mos. Supply
Highlights
Clinically studied probiotics
Gentle for infants
Easy to administer

Culturelle Baby Digestive Calm + Comfort Drops stands out as the #1 pediatrician-recommended probiotic brand, making it a trusted choice for countless parents.

It contains two of the most clinically studied probiotics proven to help with common tummy troubles and fussiness, naturally easing infant colic.

The gentle, safe ingredients ensure peace of mind, and it's incredibly easy to administer—just a quick shake and a five-drop dose.

While the dropper can be a bit tricky to use, the peace of mind it provides makes it worth it.

Overall, a solid, safe option for building a healthy foundation in your little one's first year.

Be sure to also check out the best probiotic for histamine intolerance for more options! Also, here is the price history so you know exactly when to buy!

Price history for Culturelle Baby  
on Amazon

BioGaia Protectis Baby

BioGaia Protectis Baby Probiotic Drops | Colic & Gas Relief + Vitamin D | Safe for Newborns | Ease Crying, Fussing, Colic, Gas, Spit-ups & Constipation | No Dairy, Soy & Gluten | 50 Day Supply | 10mL
Highlights
Relieves colic and gas
Safe for newborns
Natural ingredients

BioGaia Baby is a trusted choice backed by over 20 years of research, making it the most studied probiotic for colic worldwide.

It works naturally within baby's delicate digestive system to soothe fussiness, gas, spit-ups, and even occasional constipation.

Plus, it's completely safe for newborns from day one, whether breast-fed or bottle-fed.

The fact that it contains probiotics naturally found in breast milk is a major plus, promoting a happy tummy without artificial additives.

While it may be a bit pricey and require patience, many parents find it worth the wait for those calmer, more comfortable days.

Be sure to also check out the best probiotic for mouth ulcers for more options! Also, here is the price history so you know exactly when to buy!

Price history for BioGaia Protectis Baby on Amazon

Culturelle Probiotics for Babies Probiotic for Colic

Culturelle Probiotics for Babies, Colic plus Soothing Drops From Culturelle, Helps Soothe Colic, Fussiness and Crying in Babies 0-12 Months, 7.5ml drops, One Month's Supply
Highlights
Helps soothe fussiness
Supports digestive health
Easy to administer

Culturelle Baby Colic plus Soothing Probiotic Drops offers a gentle, natural way to help soothe your little one's fussiness caused by digestive discomfort.

The inclusion of 100% of the daily vitamin D boost makes it a smart choice for supporting strong bones.

It's easy to use — just five drops a day directly into the mouth or bottle, making it super convenient for busy parents.

Plus, it features safe, natural ingredients and is free from common allergens like dairy, gluten, and soy.

While the bottle size is small and a bit pricier, its effectiveness in supporting your baby's digestive health makes it a solid pick.

Be sure to also check out the best probiotic for low fodmap for more options! Also, here is the price history so you know exactly when to buy!

Price history for Culturelle Probiotics for Babies on Amazon

MaryRuth Organics Baby Probiotic Drops

MaryRuth Organics Baby Probiotic Drops | Liquid Precision Probiotics for Digestive Health | Colic Calm | Occasional Colic Baby Relief | USDA Organic | Vegan | Baby Essentials| 30 Servings
Highlights
Clinically Studied Strains
Supports Gut Health
Easy to Administer

MaryRuth’s Organic Infant Probiotic Drops are clinically studied with proven strains like Pediococcus pentosaceus and Bifidobacterium longum, targeting those pesky colic symptoms.

The easy-to-drop liquid formula makes administration a breeze—just up to 5 drops daily—and it’s suitable for babies 0-12 months.

Plus, it’s organic, vegan, and free from common allergens, making it a safe choice for sensitive tummies.

While some parents have mentioned minor issues like bottle clogging or messiness, overall, this probiotic supports gut health and may help reduce crying, making it a solid pick in our review.

Be sure to also check out the best probiotic for hemorrhoids for more options! Also, here is the price history so you know exactly when to buy!

Price history for MaryRuth Organics Baby Probiotic Drops on Amazon

Mylicon

Infants' Mylicon Daily Probiotic Drops, for Colic and Fussiness, 8mL, 21 Daily Doses
Highlights
Clinically reduces crying
Supports immune health
Easy to use

Infants' Mylicon Daily Probiotic Drops are a game-changer for easing colic discomfort.

They’re clinically proven to reduce crying and fussiness when used regularly, helping your little one feel calmer faster.

Plus, they support a healthy immune system by replenishing beneficial bacteria depleted during antibiotics or illness.

The drops are versatile—just add to a bottle, feed directly, or apply on the breast—making it super convenient for busy parents.

Safe and free from common allergens like gluten, dairy, and nuts, these drops are a trusted choice by many.

We love how simple and effective they are for calming those restless little tummies.

Be sure to also check out the best probiotics for gallbladder for more options! Also, here is the price history so you know exactly when to buy!

Price history for Mylicon on Amazon

MaryRuth Organics Probiotic for Colic

MaryRuth Organics USDA Organic Infant Liquid Probiotic Drops | Baby Essentials | Probiotics for Infants | Baby Probiotic Drops | Proprietary Probiotic Blend | Vegan | Non GMO | 125 Servings
Highlights
Supports infant gut health
Easy to administer drops
Organic and allergen-free

MaryRuth's Infant Probiotic Drops are a top contender for soothing colic thanks to their organic, allergen-free formulation.

The drops are super easy to give — just a single drop directly in your baby's mouth or added to a drink.

The blend features five probiotic strains, including Bacillus coagulans, designed to support healthy gut development.

While the CFU count is modest, the clean, vegan, and hypoallergenic profile makes it a great choice for sensitive tummies.

Plus, the certified organic label provides peace of mind.

Overall, a gentle, high-quality option for your little one.

Be sure to also check out the best probiotics for fibromyalgia for more options! Also, here is the price history so you know exactly when to buy!

Price history for MaryRuth Organics on Amazon

Pink Stork

Pink Stork Baby Probiotic Drops, Newborn, Infant & Toddler Probiotics to Help Aid Digestion and Constipation Support, Newborn Essentials - 1 fl oz, 2 Month Supply
Highlights
Supports healthy digestion
Easy to administer
No artificial ingredients

Pink Stork’s Baby Probiotic Drops deliver 1 billion CFU of Lactobacillus rhamnosus—the most studied probiotic strain—recommended by pediatricians.

The no-drip syringe makes administering a breeze, fitting seamlessly into busy parents' routines.

Plus, it’s vegan, gluten-free, and free of artificial ingredients, aligning with clean-eating values.

While some have noted packaging issues, the probiotic’s support for digestive comfort and immune health* makes it a solid choice for easing fussiness and gas.

Ultimately, it’s a reliable, kid-friendly probiotic that parents can trust for daily digestive support.

Be sure to also check out the best probiotics for osteoporosis for more options! Also, here is the price history so you know exactly when to buy!

Price history for Pink Stork on Amazon

Wellements Organic Baby Probiotic

Wellements Organic Baby Probiotic Drops (0.25 Fl Oz) - Digestive & Immune Support for Infants - Toddler Probiotic Helps with Newborn+ Gut Health, Gas, Constipation & Colic Support - Preservative Free
Highlights
Supports digestive health
Clean, organic ingredients
reduces fussiness

The Organic Probiotic Drops from Wellements are a natural, gentle way to support your baby’s gut health.

Made with high-quality probiotics like LactoSpore Bacillus coagulans and organic MCT oil, these drops are certified organic, vegan, and free from artificial nasties.

They seamlessly blend into breast milk or formula, making administration super easy—simply drop, mix, and go!

While they do require refrigeration and come with a slightly higher price point, their effectiveness in reducing fussiness and supporting overall digestion makes them a star choice for concerned parents seeking a safe and reliable probiotic for colic relief.

Be sure to also check out the best probiotics for gout for more options! Also, here is the price history so you know exactly when to buy!

Price history for Wellements Organic Baby Probiotic on Amazon

Mommy's Bliss Probiotic for Colic

Mommy's Bliss Baby Probiotic Drops + Vitamin D, Supports Digestive Health and Immunity, 400IU Vitamin D for Healthy Bone Development, Newborns +, Flavorless, 0.34 Fl Oz (30 Servings)
Highlights
Easy to administer
Tasteless drops
Supports digestion

Mommy's Bliss Baby Probiotic Drops + Vitamin D are gentle, safe, and easy to use — perfect for even the tiniest tummies.

The tasteless drops make administration a breeze, and the added Vitamin D helps support overall immune health.

While some parents might wish for more extensive review data or quicker results, its reputation for supporting digestion and easing colic is well-earned.

Just remember to be available during delivery to avoid melting issues!

Overall, it's a trusted choice that offers healthy, happy babies and peace of mind for parents.

Be sure to also check out the best probiotic for sugar cravings for more options! Also, here is the price history so you know exactly when to buy!

Price history for Mommy's Bliss on Amazon

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